Source: Romanian Journal of Urology.
Dec, Vol. Author s : Iordache, A. Abstract: Scientific context: Prostate cancer is the most common noncutaneous cancer and represents the second cause of mortality through neoplasia in United States and the EU. In Romania the incidence varies according to age, range from perpeople, reaching a maximum at the age group years.
PSA prostate-specific antigen is a glycoprotein produced by prostatic epithelial cells.
Vă recomandăm să contactaţi recepţia pentru mai multe informaţii. Informaţii generale şi recomandări pentru determinarea free-PSA Antigenul specific prostatic PSA este un component esenţial al plasmei seminale, având o greutate moleculară de 33 kDa. Este sintetizat în celulele acinare şi în epiteliul ductal al prostatei sub controlul hormonilor androgeni testosterondihidrotestosterondupă care este secretat în sistemul ductal unde atinge concentraţii mari. Se pare că PSAprin funcția de serin-protează, are rol în liza coagulului seminal, fiind implicat astfel în fertilitatea masculină.
Disruption prostate structure can lead to download large quantities of PSA in systemic circulation. Purpose: Analysis of the predictive value of clinical and paraclinical parameters for identification patients with prostate cancer.
Objectives: 1. Generating predictive value and validity of tests considered - PSA, Free PSA and local clinical examination followed by descriptive evaluation of therapeutic decision for patients with positive diagnosis. Methodology: The study population consisted of patients hospitalized in the Surgery Center of Urology and Renal Transplantation "Fundeni" during march - july The study population was submitted for inclusion free psa normal values exclusion criteria and standard protocol for low urinary tract symptoms.
Results: Average age of patients enrolled was 63 years, most patients were from urban areas. For PSA we obtained: sensitivity For Free PSA values are: Sensitivity calculated for local clinical examination is Positive predictive value is Specificity adjustment may occur free psa normal values increasing the number of cores collected by transrectal biopsy and decrease the threshold for positivity of PSA and increase for Free PSA.
The detection free psa normal values in the studied group does not increase with increasing the number of cores, which suggests that the majority of study population included has positive ultrasound lesions. PSA value correlates with the aggressiveness of the disease and second with its prognosis.
PSA becomes also a prognostic marker for the group studied.
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